Correl CCSVI Venogramation of localization and severity of extra-cranial venous lesions with clinical status of multiple sclerosis
Chronic cerebrospinal venous insufficiency is suspected to play a role in pathogenesis of multiple sclerosis.
Assessment of the correlations between patterns of venous lesions and clinical characteristics of multiple sclerosis.
Localization and degree of venous blockages in multiple sclerosis 381 patients were evaluated using catheter venography. Analysis of clinical severity included: Multiple Sclerosis Impact Scale-29 (MSIS-29), chronic fatigue and heat intolerance assessment.
Venous blockages were found in 97.1% of the patients.
Abnormalities were more severe in older patients. No correlation existed between duration of the disease and severity of venous pathologies. Patients with younger age at onset of multiple sclerosis presented with milder venous lesions. Significant correlations existed between severity and localization of venous lesions and clinical burden in terms of MSIS-29 and chronic fatigue scores, but not of heat intolerance.
Prevalence of chronic cerebrospinal venous insufficiency among multiple sclerosis patients is very high. Indirect data analysis indicated that venous abnormalities are probably congenital, slowly progress, but are unlikely to be caused by multiple sclerosis.
Their severity and localization significantly modify clinical course of this disease. However, they are not likely to directly trigger multiple sclerosis, but there may be another factor initiating the disease.
Simka M, Ludyga T, Kazibudzki M, Latacz P,
?wierad M, Piegza J
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EUROMEDIC Specialist Clinics, Department of Vascular & Endovascular Surgery, Katowice; Poland.
Euromedic Specialist Clinics (31/08/10)